Product Description

• AIRSUPRA is a pressurized inhalation suspension combining 90 mcg of salbutamol (a short-acting beta2-agonist) and 80 mcg of budesonide (an inhaled corticosteroid) per actuation.


• It is indicated for the as-needed treatment or prevention of bronchoconstriction and the reduction of exacerbation risk in asthma patients aged 18 and older.


• Clinical studies, such as MANDALA and DENALI, demonstrate that the combination significantly reduces severe asthma exacerbations and improves lung function compared to monotherapies.

How To Use

• For relief of bronchoconstriction, administer 2 actuations (delivering a total of 180 mcg salbutamol and 160 mcg budesonide) as needed.


• For prevention of exercise-induced bronchoconstriction, administer 2 actuations 15 to 30 minutes prior to physical activity.


• Do not exceed a maximum of 6 doses (12 inhalations) within a 24-hour period.


• No dosage adjustment is required for elderly patients; however, safety and effectiveness have not been established for adolescents aged 12 to 17.

Warnings And Precautions

• Contraindicated in patients with known hypersensitivity to salbutamol, budesonide, or any of the formulation excipients.


• Patients should seek immediate medical advice if they experience a paradoxical bronchospasm or if increased bronchodilator use is required, as this indicates worsening asthma control.


• Use with caution in patients with cardiovascular disorders (e.g., severe heart disease, hypertension), thyrotoxicosis, or hypokalaemia.


• Usage during pregnancy or breastfeeding should only be considered if the expected benefit to the mother outweighs the potential risks to the fetus or infant.


• Avoid concomitant use with non-selective beta-blockers and exercise caution with strong CYP3A4 inhibitors (e.g., ketoconazole).

Ingredients

• Active Ingredients: Salbutamol (90 mcg per actuation) and Budesonide (80 mcg per actuation).


• Propellant: Norflurane (HFA-134a).


• Excipients: 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) and Calcium Chloride.