Product Name

Aprizla 30 mg Tablets

Active Ingredient

Apremilast 30 mg

Dosage Form

Film-coated tablets – Oral use

What is Aprizla used for?

Aprizla is an anti-inflammatory medicine belonging to a group called phosphodiesterase 4 (PDE4) inhibitors. It is used in adults to treat:

• 
  

  Active psoriatic arthritis
  (when other treatments such as DMARDs are not suitable or have not worked)

  
  


• 
  

  Moderate to severe chronic plaque psoriasis
  (when treatments like phototherapy or systemic therapy are unsuitable or ineffective)

  
  

How Aprizla Works

Aprizla reduces inflammation by lowering the activity of the enzyme phosphodiesterase 4, which plays a role in inflammatory processes.
This helps:

• 
  

  Reduce joint pain and swelling in psoriatic arthritis

  
  


• 
  

  Improve skin plaques and symptoms of psoriasis

  
  


• 
  

  Enhance overall quality of life

  
  

Dosage & Administration

• 
  

  Treatment starts with a gradual dose increase over the first 6 days

  
  


• 
  

  Recommended maintenance dose:
  30 mg twice daily (morning and evening, about 12 hours apart)

  
  


• 
  

  Total daily dose: 60 mg

  
  


• 
  

  Tablets should be swallowed whole with water

  
  


• 
  

  Can be taken with or without food

  
  

For severe kidney impairment:
Recommended dose is 30 mg once daily (morning only)

Warnings & Precautions

Do not use Aprizla if:

• 
  

  You are allergic to apremilast or any of the ingredients

  
  


• 
  

  You are pregnant or planning pregnancy

  
  

Consult your doctor if you:

• 
  

  Have depression or mood changes

  
  


• 
  

  Experience unexplained weight loss

  
  


• 
  

  Have severe kidney problems

  
  


• 
  

  Develop severe diarrhea, nausea, or vomiting

  
  

Drug Interactions

Tell your doctor if you take:

• 
  

  Rifampicin

  
  


• 
  

  Carbamazepine, phenytoin, phenobarbital

  
  


• 
  

  St John’s Wort

  
  

Possible Side Effects

Very common:

• 
  

  Diarrhea

  
  


• 
  

  Nausea

  
  


• 
  

  Headache

  
  


• 
  

  Upper respiratory infections

  
  

Common:

• 
  

  Vomiting

  
  


• 
  

  Stomach pain

  
  


• 
  

  Loss of appetite

  
  


• 
  

  Insomnia

  
  


• 
  

  Depression

  
  

Uncommon but serious:

• 
  

  Mood changes or suicidal thoughts

  
  


• 
  

  Severe allergic reactions

  
  


• 
  

  Unintended weight loss

  
  

Seek medical help immediately if severe side effects occur.

Storage Instructions

• 
  

  Store below 30°C

  
  


• 
  

  Keep out of reach of children

  
  


• 
  

  Do not use after expiry date

  
  


• 
  

  Do not use if packaging is damaged

  
  

Pack Information

• 
  

  Each tablet contains Apremilast 30 mg

  
  


• Contain Lactpse