What Canagliflozin is used for:

• Canagliflozin is used to treat adults with type 2 diabetes.

Do not take Canagliflozin:

• if you are allergic to Canagliflozin or any of the other ingredients of this medicine.

Warnings and precautions:

Talk to your doctor or pharmacist before taking Canagliflozin, and during treatment:

• about what you can do to prevent dehydration.


• if you have type 1 diabetes because Canagliflozin should not be used to treat this condition.


• if you experience rapid weight loss, feeling sick or being sick, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, a sweet or metallic taste in your mouth or a different odour to your urine or sweat, talk to a doctor or go to the nearest hospital immediately.


• if you have diabetic ketoacidosis (a complication of diabetes with high blood sugar, rapid weight loss, nausea, or vomiting).


• if you have severe kidney problems or are on dialysis.


• if you have severe liver problems.


• if you have ever had serious heart disease or if you have had a stroke.


• if you are on medicines to lower your blood pressure (anti-hypertensives) or have ever had low blood pressure (hypotension).


• if you have had a lower limb amputation.


• It is important to check your feet regularly and adhere to any other advice regarding foot care and adequate hydration given by your healthcare professional.


• Talk to your doctor immediately if you develop a combination of symptoms of pain, tenderness, redness, or swelling of the genitals or the area between the genitals and the anus with fever or feeling generally unwell.


• if you have signs of a genital yeast infection such as irritation, itching, unusual discharge or odour.

Possible side effects :

• Some serious side effects include: Severe allergic reaction, diabetic ketoacidosis and dehydration.

Other side effects include:

• Hypoglycaemia: when taking this medicine with insulin or a sulphonylurea (such as glimepiride or glipizide)


• Urinary tract infections


• Vaginal yeast infection


• Rash or redness of the penis or foreskin (yeast infection)


• Changes in urination


• Constipation


• Feeling thirsty


• Nausea

Other medicines and Canagliflozin:

• Tell your doctor if you are taking any of the following medicines:

other antidiabetics - either insulin or a sulphonylurea (such as glimepiride or glipizide).

• medicines used to lower your blood pressure (anti-hypertensives), including diuretics since this medicine can also lower your blood pressure by removing levels of excess water in the body.


• John’s wort (an herbal medicine to treat depression)


• carbamazepine, phenytoin, or phenobarbital (medicines used to control seizures)


• efavirenz or ritonavir (a medicine used to treat HIV infection)


• rifampicin (an antibiotic used to treat tuberculosis)


• cholestyramine (medicine used to reduce cholesterol levels in the blood).


• digoxin or digitoxin (medicines used for certain heart problems).


• dabigatran (blood thinner medicine that lowers the risk of blood clot formation).

How to take Canagliflozin:

• The starting dose of Canagliflozin is one 100 mg tablet each day.


• Your doctor will decide whether to increase your dose to 300 mg.


• Your doctor may limit your dose to 100 mg if you have a kidney problem.


• Your doctor will prescribe the strength that is right for you.

Taking this medicine:

• Swallow the tablet whole with water.


• You can take your tablet with or without food.


• It is best to take your tablet before the first meal of the day.


• Try to take it at the same time each day.


• This will help you remember to take it.


• If your doctor has prescribed Canagliflozin along with any bile acid sequestrant such as cholestyramine (medicines for lowering cholesterol) you should take Canagliflozin at least 1 hour before or 4 hours to 6 hours after the bile acid sequestrant.

How to store Canagliflozin:

• Keep this medicine out of the sight and reach of children.


• Do not use this medicine after the expiry date which is stated on the blister and carton after EXP.


• The expiry date refers to the last day of that month.


• This medicine does not require any special storage conditions.


• Do not use Canagliflozin if the packaging is damaged or shows signs of tampering.