Product Description:

• Sterile Water for Injection USP is a clear, colorless, odorless liquid. It is sterile, hypotonic, nonpyrogenic, and contains no bacteriostatic or antimicrobial agents. Sterile Water for Injection USP is a diluent or solvent suitable for intravascular injection after first having been made approximately isotonic by the addition of suitable solute.


• pH: 5.5 (5.0–7.0)


• Not made with natural rubber latex, PVC or DEHP.


• The plastic container is made from a multilayered film specifically developed for parenteral drugs. It contains no plasticizers and exhibits virtually no leachables. The solution contact layer is a rubberized copolymer of ethylene and propylene. The container is nontoxic and biologically inert.


• The container-solution unit is a closed system and is not dependent upon entry of external air during administration. The container is overwrapped to provide protection from the physical environment and to provide an additional moisture barrier when necessary.

How To Use:

• Your doctor will decide the correct amount of Water For Injection 5 ml to be dissolved or diluted for the medication that you are receiving as an injection.• Water For Injection 5 ml will be administered by the doctor or healthcare professional.• Do not self-administer.

Benefits:

• Water For Injection 5 ml is a diluent vehicle that contains clear, colourless, odourless water. It is sterile and contains no antimicrobial agents or other added buffers. Water For Injection 5 ml is intended for dissolving and diluting drugs, which are meant for parenteral use. Water For Injection 5 ml is also used to wash small wounds and during minor surgical procedures.

How Water For Injection 5 ml Works?

• Water For Injection 5 ml contains clear, colourless, odourless water. It is sterile and contains no antimicrobial agents or other added buffers. Water For Injection 5 ml is intended for dissolving and diluting drugs, which are meant for parenteral use (administration of drugs from routes other than mouth and alimentary canal).

Storage:

• Keep out of sight and reach of children.


• What if I have taken an overdose of Water For Injection 5 ml


• Overdose with Water For Injection 5 ml is unlikely as it is used for the reconstitution and preparation of aqueous injections.

Warnings

• Let your doctor know if you are allergic to Water For Injection 5 ml or its inactive components. Brief your medical history to the doctor if you have any heart, liver or kidney diseases before starting Water For Injection 5 ml.


• Water For Injection 5 ml should be administered after being made isotonic (same salt concentration as cells and blood) by adding an appropriate solute to prevent any haemolysis (breakdown of red blood cells).


• Water for Injection may sometimes contain aluminium, which may alter kidney function. Hence, care should be taken accordingly.


• Water For Injection 5 ml should be used during pregnancy and breastfeeding only when advised by your doctor.


• The product may interact with the plastic container and leach out its contents in small amounts at higher temperatures. Hence, do not store Water For Injection 5 ml above 25°C.

Side Effects:

• Refer to the package insert of the solute used.


• Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.


• The physician should also be alert to the possibility of adverse reactions to drug additives. Prescribing information for drug additives to be administered in this manner should be consulted.


• If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.

Overdosage:

• Overdosage (hypotonic expansion) is a function of an increase in fluid intake over fluid output, and occurs when the increase in the volume of body fluids is due to water alone.


• Overdosage may occur in patients who receive large quantities of electrolyte-free water to replace abnormal excessive fluid losses, in patients whose renal tolerance to water loads is exceeded, or in patients who retain water postoperatively in response to stress.


• Manifestations of water intoxication are behavioral changes (confusion, apathy, disorientation and attendant hyponatremia), central nervous system disturbances (weakness, muscle twitching, headaches, nausea, vomiting, convulsions) and weight gain.


• Treatment consists of withholding fluids until excessive water is excreted. In severe hyponatremia it may be necessary to cautiously administer hypertonic saline to increase extracellular osmotic pressure and excretion of excess water by the kidneys.